ALL Essay - 1552 Words

Signs and Symptoms The signs and symptoms of ALL can present chronically or acutely, they are normally found during a routine blood count of an asymptomatic child or during a life-threatening hemorrhage, infection, or episode of respiratory distress. Although ALL is a disease primarily of the bone marrow and peripheral blood, any organ or tissue may be infiltrated by the abnormal cells. The symptoms in children can have a much longer duration due to ALL has varies amounts of onset which may last from days to months. The first symptoms are usually non- specific and include anorexia, irritability and lethargy. Fever is the most common finding, occurring in approximately 60% of patients. Progressive bone marrow failure leads to pallor†¦show more content†¦Patients with ALL generally have a higher than normal white blood count and lower than normal red blood cell and platelet counts. Blood tests are also performed to evaluate liver, kidney, and blood clotting status. The physician will also check the levels of certain minerals and proteins for an accurate diagnosis. The next step will be to perform a bone marrow biopsy, pending the blood test results. If the results are abnormal or the doctor suspects leukemia despite normal cell counts, a bone marrow aspiration and biopsy are the next steps. These are very common and safe procedures. Then, if bone marrow examination confirms ALL, a spinal tap will be the next step, which means a needle will be inserted into the spinal canal and cerebrospi nal fluid with leukemia cells will be collected and will be analyzed for signs that the disease has spread to the central nervous system. In most cases of childhood ALL, leukemia cells are not found in the cerebrospinal fluid. Disease Progression There are two main types of ALL acute and chronic. Acute leukemia develops very quickly, while chronic leukemia tends to develop slowly, usually over a period of months or years without causing many symptoms. 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